• AS Roma 4-1 Feyenoord (Leonardo Spinazzola 60′, Paulo Dybala 89′, Stephan El Shaarawy 101′, Lorenzo Pellegrini 109′; Igor Paixao 80′) – Agregat 4-2
• Union SG 1-4 Bayer Leverkusen (Casper Terho 64′; Moussa Diaby 2′, Mitchel Bakker 37′, Jeremie Frimpong 60′, Adam Hlozek 79′) – Agregat 2-5
• Sevilla 3-0 Manchester United (Youssef En-Nesyri 8′, 81′, Loic Bade 47′) – Agregat 5-2
• Sporting CP 1-1 Juventus (Marcus Edwards 20′-pen; Adrien Rabiot 9′) – Agregat 1-2
Jadwal Semifinal Liga Europa 2022-2023:
